The OBD-II specification is the same for all vehicles 1996 and newer, but the electrical characteristics of the communication bus for relaying the OBD-II information will vary. Therefore, the ProScan software can be used to analyze any OBD-II vehicle providing that there exists an electrical interface to convert the vehicle's communication format into that of a computer's serial port (RS-232).

ProScan currently has interface hardware for the following electrical formats:

Note: Vehicles 2003 and newer are beginning to support a new format known as CAN (Controller Area Network). ProScan does not currently have a CAN interface, but work is underway.